Comparison 4. Failure to extubate.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Failure to extubate by 3rd day	9	408	Risk Ratio (M‐H, Fixed, 95% CI)	0.76 [0.69, 0.84]
2 Failure to extubate by 7th day	15	761	Risk Ratio (M‐H, Fixed, 95% CI)	0.65 [0.59, 0.72]
3 Failure to extubate by 14th day	4	124	Risk Ratio (M‐H, Fixed, 95% CI)	0.63 [0.45, 0.90]
4 Failure to extubate by 28th day	3	236	Risk Ratio (M‐H, Fixed, 95% CI)	0.58 [0.37, 0.89]