Kari 1993.
| Methods | Multi‐centre double‐blind randomised controlled trial | |
| Participants | 41 preterm infants 10 days old, weighing < 1500 grams with gestational age > 23 weeks, and ventilator‐dependent Exclusions: PDA, sepsis, GI bleeding, major malformation |
|
| Interventions | Dexamethasone 0.5 mg/kg/d given intravenously 12‐hourly for 7 days Infants in the control group received normal saline as a placebo. | |
| Outcomes | BPD, duration of IPPV, hypertension, hyperglycaemia, sepsis, perforated colon, cryotherapy for ROP | |
| Notes | — | |
| Risk of bias | ||
| Bias | Authors' judgement | Support for judgement |
| Random sequence generation (selection bias) | Unclear risk | Random allocation: method not stated |
| Allocation concealment (selection bias) | Low risk | Allocation concealment: yes |
| Blinding (performance bias and detection bias) All outcomes | Low risk | Blinding of intervention: yes |
| Blinding of participants and personnel (performance bias) All outcomes | Low risk | Blinding of intervention: yes |
| Blinding of outcome assessment (detection bias) All outcomes | Low risk | Blinding of outcome measurement: yes |
| Incomplete outcome data (attrition bias) All outcomes | Low risk | Complete follow‐up: yes |
| Selective reporting (reporting bias) | Unclear risk | All prespecified outcomes reported |