| Study | Reason for exclusion |
|---|---|
| Anttila 2005 | Early neonatal dexamethasone treatment for prevention of bronchopulmonary dysplasia ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Armstrong 2002 | Follow‐up study of 2 different dexamethasone regimens without an untreated control group |
| Ashton 1994 | No clinical outcomes assessed |
| Baden 1972 | Controlled trial of hydrocortisone therapy in infants with respiratory distress syndrome ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Batton 2012 | Feasibility study of early blood pressure management in extremely preterm infants ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Biswas 2003 | Pulmonary effects of triiodothyronine (T3) and hydrocortisone (HC) supplementation in preterm infants at less than 30 weeks' gestation ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Bloomfield 1998 | 2 different courses of dexamethasone compared; no placebo control group |
| Bonsante 2007 | Randomised placebo‐controlled trial of early low‐dose hydrocortisone in very preterm infants ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Couser 1992 | Dexamethasone given only to facilitate extubation; no long‐term data reported |
| Cranefield 2004 | 2 dexamethasone regimens compared without an untreated control group |
| Durand 2002 | 2 different courses of dexamethasone compared without a placebo control group |
| Efird 2005 | Randomised controlled trial of prophylactic hydrocortisone supplementation for prevention of hypotension in extremely low birth weight infants ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Ferrara 1990 | Single dose of intravenous dexamethasone given before extubation; no long‐term outcome data reported |
| Garland 1999 | Randomised controlled trial of a 3‐day course of dexamethasone therapy to prevent bronchopulmonary dysplasia in ventilated neonates ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Groneck 1993 | No clinical outcomes reported |
| Halac 1990 | Controlled trial of prenatal and postnatal corticosteroid therapy to prevent neonatal necrotising enterocolitis ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Kopelman 1999 | Single very early dexamethasone dose improves respiratory and cardiovascular adaptation in preterm infants ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Lin 1999 | Prevention of bronchopulmonary dysplasia in preterm infants by early postnatal dexamethasone therapy ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Mammel 1983 | Randomised trial with a cross‐over design so that all infants were treated at some time with dexamethasone |
| Merz 1999 | Dexamethasone started at 7 or 14 days with no placebo control group |
| Mukhopadhyay 1998 | Role of early postnatal dexamethasone in respiratory distress syndrome ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Ng 2006 | Double‐blind randomised controlled study of a stress dose of hydrocortisone for rescue treatment of refractory hypotension in preterm infants ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Odd 2004 | 2 dexamethasone regimens compared without an untreated control group |
| Peltoniemi 2005 | Trial of early neonatal hydrocortisone administration for prevention of bronchopulmonary dysplasia in high‐risk infants ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Rastogi 1996 | Randomised controlled trial of dexamethasone to prevent bronchopulmonary dysplasia in surfactant‐treated infants ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Romagnoli 1999 | Controlled trial of early dexamethasone treatment for prevention of bronchopulmonary dysplasia in preterm infants ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Sanders 1994 | 2 doses of early intravenous dexamethasone for prevention of bronchopulmonary dysplasia in babies with respiratory distress syndrome ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review |
| Shinwell 1996 | Early postnatal dexamethasone treatment to prevent bronchopulmonary dysplasia in infants with respiratory distress syndrome ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Sinkin 2000 | Early dexamethasone ‐ attempting to prevent bronchopulmonary dysplasia ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Soll 1999 | Early postnatal dexamethasone therapy for prevention of bronchopulmonary dysplasia ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Stark 2001 | Randomised trial of early dexamethasone to prevent death or bronchopulmonary dysplasia in extremely low birth weight infants ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Subhedar 1997 | Open randomised controlled trial of inhaled nitric oxide and early dexamethasone in high‐risk preterm infants ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Suske 1996 | Effects of early postnatal dexamethasone therapy on ventilator dependency in surfactant‐substituted preterm infants ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Tapia 1998 | Early dexamethasone administration for bronchopulmonary dysplasia in preterm infants with respiratory distress syndrome ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Wang 1996 | Measurement of pulmonary status and surfactant protein levels during dexamethasone treatment for neonatal respiratory distress syndrome ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Watterberg 2004 | Prophylaxis of early adrenal insufficiency to prevent bronchopulmonary dysplasia: a multi‐centre trial ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Wilson 1988 | Reported only short‐term hormonal changes; no long‐term outcome data |
| Yeh 1990 | Early postnatal dexamethasone therapy in premature infants with severe respiratory distress syndrome: a double‐blind, controlled study ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Yeh 1997 | Early postnatal dexamethasone therapy for prevention of bronchopulmonary dysplasia in preterm infants with respiratory distress syndrome: a multi‐centre clinical trial. ‐ in "Early (< 8 days) systemic postnatal corticosteroids for preventing bronchopulmonary dysplasia in preterm infants" review (Doyle 2017) |
| Yoder 1991 | No clinical outcomes assessed |
HC: hydrocortisone. T3: triiodothyronine.