Drug	Dose (mg)	Number of		At least 50% maximum pain relief over 4 ‐ 6 hours						Susceptibility to publication bias
				Number with outcome/total		Percent with outcome		Risk ratio (95% CI)	NNT (95% CI)
		Studies	Participants	Active	Placebo	Active	Placebo
Dextropropoxyphene	65	6	440	85/214	60/226	40	27	1.5 (1.2 to 1.9)	7.7 (4.6 to 22)	131
Diflunisal	250	3	195	49/98	16/97	47	16	2.9 (1.8 to 4.6)	3.3 (2.3 to 5.5)	396
Diclofenac fast‐acting	25	2	325	36/165	4/160	22	3	8.7 (3.2 to 24)	5.2 (3.8 to 8.0)	325
Diclofenac sodium	50	2	313	58/193	18/120	30	15	2.0 (1.3 to 3.3)	6.6 (4.1 to 17)	161
Dihydrocodeine	30	3	194	31/97	19/97	32	20	1.6 (1.01 to 2.5)	8.1 (4.1 to 540)	46
Etodolac	50	4	360	44/154	34/206	29	17	1.7 (1.1 to 2.6)	8.3 (4.8 to 30)	74
Gabapentin	250	3	327	26/177	8/150	15	5	2.5 (1.2 to 5.0)	11 (6.4 to 35)	NNT above 10
Ibuprofen	50	3	316	50/159	16/157	31	10	3.2 (1.9 to 5.1)	4.7 (3.3 to 8.0)	356
Mefenamic acid	500	2	256	60/126	29/130	48	22	2.1 (1.5 to 3.1)	4.0 (2.7 to 7.1)	384
Naproxen	200/220	2	202	54/120	13/82	45	16	2.9 (1.6 to 5.1)	3.4 (2.4 to 5.8)	392
Oxycodone	15	3	228	61/113	37/115	54	32	1.7 (1.2 to 2.3)	4.6 (2.9 to 11)	268
Paracetamol + codeine	300+30	6	690	123/379	56/311	32	18	1.9 (1.4 to 2.5)	6.9 (4.8 to 12)	310
Paracetamol + oxycodone	325+5	3	388	60/221	14/167	27	8	3.6 (2.1 to 6.3)	5.4 (3.9 to 8.8)	331