Drug	Dose (mg)	Number of		At least 50% maximum pain relief over 4 ‐ 6 hours						Susceptibility to publication bias
				Number with outcome/total		Percent with outcome		Risk ratio (95% CI)	NNT (95% CI)
		Studies	Participants	Active	Placebo	Active	Placebo
Aspirin	600/650	65	4965	983/2496	379/2469	39	15	2.5 (2.3 to 2.8)	4.2 (3.8 to 4.6)	6856
Aspirin	1000	6	618	138/340	40/278	41	14	2.7 (2.0 to 3.7)	4.2 (3.8 to 4.6)	853
Aspirin	1200	3	249	85/140	25/109	62	19	3.3 (1.8 to 6.3)	2.4 (1.9 to 3.2)	789
Celecoxib	200	4	705	149/423	32/282	35	11	3.5 (2.4 to 5.1)	4.2 (3.4 to 5.6)	974
Celecoxib	400	5	722	202/466	12/256	43	5	10 (5.7 to 18)	2.6 (2.3 to 3.0)	2055
Codeine	60	33	2411	311/1199	209/1212	26	17	1.5 (1.3 to 1.7)	12 (8.4 to 18)	NNT above 10
Dexketoprofen	10/12.5	5	452	104/230	38/222	45	17	2.7 (2.0 to 3.7)	3.6 (2.8 to 5.0)	804
Dexketoprofen	20/25	6	523	129/225	38/248	47	15	3.3 (2.4 to 4.5)	3.2 (2.6 to 4.1)	1111
Diclofenac fast acting	50	4	486	156/214	46/232	61	20	2.9 (3.2 to 3.8)	2.4 (2.0 to 3.0)	1539
Diclofenac potassium	25	4	502	140/248	37/274	56	15	3.9 (2.8 to 5.3)	2.4 (2.0 to 2.9)	1590
Diclofenac potassium	50	7	757	253/398	60/359	64	17	3.7 (2.9 to 4.7)	2.1 (1.9 to 2.5)	2848
Diclofenac potassium	100	6	589	196/300	39/289	65	13	4.8 (3.6 to 6.5)	1.9 (1.7 to 2.3)	2511
Diflunisal	500	6	391	104/198	27/193	53	14	3.8 (2.6 to 5.4)	2.6 (2.1 to 3.3)	1113
Diflunisal	1000	5	357	112/182	26/175	62	15	4.1 (2.9 to 6.0)	2.1 (1.8 to 2.6)	1343
Dipyrone	500	5	288	106/143	45/145	74	31	2.4 (1.8 to 3.1)	2.3 (1.9 to 3.1)	964
Etodolac	100	5	498	103/251	50/247	41	20	2.0 (1.5 to 2.7)	4.8 (3.5 to 7.8)	540
Etodolac	200	7	670	145/333	44/337	44	13	3.3 (2.5 to 4.5)	3.3 (2.7 to 4.2)	1360
Etodolac	400	3	222	52/134	4/88	39	5	9.0 (3.4 to 24)	2.9 (2.3 to 4.0)	544
Etoricoxib	120	6	798	332/503	34/295	66	12	5.6 (4.0 to 7.8)	1.8 (1.7 to 2.0)	3635
Etoricoxib	180/240	2	199	129/150	6/49	79	12	6.4 (3.1 to 14)	1.5 (1.3 to 1.7)	1128
Fenoprofen	200	4	287	83/146	19/141	57	13	4.2 (2.7 to 6.4)	2.3 (1.9 to 3.0)	961
Flurbiprofen	25	3	208	36/102	5/106	35	5	7.0 (2.9 to 16)	3.3 (2.5 to 4.9)	422
Flurbiprofen	50	10	692	245/353	108/339	69	32	2.2 (1.9 to 2.6)	2.7 (2.3 to 3.3)	1871
Flurbiprofen	100	7	416	139/215	48/201	65	24	2.8 (2.2 to 3.6)	2.5 (2.0 to 3.1)	1248
Ibuprofen acid	100	4	396	60/192	16/204	31	8	3.7 (2.3 to 5.9)	4.3 (3.2 to 6.4)	525
Ibuprofen acid	200	18	2103	448/1094	67/1009	41	7	6.5 (5.1 to 8.2)	2.9 (2.7 to 3.2)	5149
Ibuprofen acid	400	51	5604	1596/3070	289/2543	52	12	4.6 (4.0 to 5.1)	2.5 (2.4 to 2.6)	16,812
Ibuprofen acid	600	3	203	88/114	36/89	77	40	2.0 (1.5 to 2.6)	2.7 (2.0 to 4.2)	549
Ibuprofen fast acting	200	7	828	270/478	34/350	57	10	5.7 (4.2 to 7.9)	2.1 (1.9 to 2.4)	3115
Ibuprofen fast acting	400	13	1364	427/658	85/466	65	18	3.9 (3.2 to 4.7)	2.1 (1.9 to 2.3)	5131
Ibuprofen + caffeine	100+100	2	200	43/99	0/101	43	0	45 (36.3 to 320)	2.4 (1.9 to 3.1)	633
Ibuprofen + caffeine	200+100	4	334	103/174	16/160	59	10	5.5 (3.5 to 8.7)	2.1 (1.9 to 3.1)	1256
Ibuprofen + codeine	400+26‐60	4	443	178/276	30/167	64	18	4.1 (2.8 to 5.9)	2.2 (1.8 to 2.6)	1571
Ibuprofen + paracetamol	200+500	3	508	240/349	10/159	69	6	10 (5.7 to 19)	1.6 (1.5 to 1.8)	2667
Ibuprofen + paracetamol	400+1000	3	543	278/384	10/159	72	6	11 (6.2 to 20)	1.5 (1.4 to 1.7)	3077
Ibuprofen + oxycodone	400+5	3	603	250/418	31/185	60	17	3.6 (2.6 to 5.1)	2.3 (2.0 to 2.8)	2019
Ketoprofen	12.5	3	274	77/138	18/136	56	13	4.2 (2.7 to 6.6)	2.4 (1.9 to 3.1)	868
Ketoprofen	25	8	535	175/281	31/254	62	12	4.9 (3.5 to 6.9)	2.0 (1.8 to 2.3)	2140
Ketoprofen	50	8	624	151/314	56/310	48	18	2.7 (2.0 to 3.5)	3.3 (2.7 to 4.3)	1267
Ketoprofen	100	5	321	106/161	28/160	66	18	3.6 (2.5 to 5.1)	2.1 (1.7 to 2.6)	1208
Lornoxicam	8	3	273	71/155	13/118	46	11	4.7 (2.7 to 8.1)	2.9 (2.3 to 4.0)	668
Lumiracoxib	400	4	578	183/366	17/212	50	8	6.9 (4.1 to 11)	2.4 (2.1 to 2.8)	1830
Naproxen	400/440	3	334	103/210	14/124	49	11	4.8 (2.8 to 8.4)	2.7 (2.2 to 3.5)	903
Naproxen	500/550	9	784	200/394	59/390	52	15	3.4 (2.6 to 4.4)	2.7 (2.3 to 3.3)	2120
Paracetamol	500	6	561	176/290	86/271	61	32	1.9 (1.6 to 2.3)	3.5 (2.7 to 4.8)	1042
Paracetamol	600/650	19	1886	358/954	145/932	38	16	2.4 (2.0 to 2.8)	4.6 (3.9 to 5.5)	2214
Paracetamol	975/1000	28	3232	876/1906	241/1329	46	18	2.7 (2.4 to 3.0)	3.6 (3.2 to 4.1)	5746
Paracetamol + codeine	600/650+60	17	1413	370/857	96/556	43	17	2.6 (2.2 to 3.2)	3.9 (3.3 to 4.7)	2210
Paracetamol + codeine	800/1000+60	3	192	64/121	5/71	53	7	6.3 (2.9 to 14)	2.2 (1.8 to 2.9)	681
Paracetamol + dextropropoxyphene	65+650	6	963	184/478	74/485	38	15	2.5 (2.0 to 3.2)	4.4 (3.5 to 5.6)	1226
Paracetamol + oxycodone	650+10	10	1043	346/680	49/363	51	14	3.9 (2.9 to 5.2)	2.7 (2.4 to 3.1)	2820
Paracetamol + oxycodone	1000+10	2	289	100/147	19/142	68	13	4.9 (3.2 to 7.6)	1.8 (1.6 to 2.2)	1317
Piroxicam	20	3	280	89/141	36/139	63	26	2.5 (1.8 to 3.3)	2.7 (2.1 to 3.8)	757
Rofecoxib	50	25	3688	1458/2519	134/1169	58	11	5.1 (4.3 to 6.1)	2.2 (2.0 to 2.3)	13,076