| Drug | Dose (mg) | Pain condition | Number of | At least 50% maximum pain relief over 4‐6 hours |
Susceptibility to publication bias |
||||||
| Number on | Percent with outcome | Risk ratio (95% CI) | NNT (95% CI) | ||||||||
| Studies | Participants | Active | Placebo | Active | Placebo | ||||||
| Tramadol | 50 | Dental | 6 | 471 | 41/246 | 13/225 | 17 | 6 | 2.9 (1.6 to 5.2) | 9.1 (6.1 to 19) | 47 |
| Tramadol | 100 | Dental | 7 | 578 | 89/300 | 22/278 | 30 | 8 | 3.8 (2.4 to 5.8) | 4.6 (3.6 to 6.4) | 679 |
| Tramadol | 100 | Other surgery | 4 | 304 | 51/168 | 13/136 | 30 | 10 | 3.2 (1.8 to 5.6) | 4.8 (3.4 to 8.2) | 329 |
| Tramadol | 150 | Other surgery | 5 | 371 | 106/184 | 31/187 | 60 | 17 | 3.5 (2.4 to 4.9) | 2.4 (2.0 to 3.1) | 1175 |
| Tramadol + paracetamol |
75/650 | Dental | 5 | 659 | 128/340 | 11/339 | 40 | 3 | 12 (6.4 to 21) | 2.9 (2.5 to 3.5) | 1613 |
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