Table 1.

Significantly mutated genes and their distributions in the main cytogenetic subgroups.

Gene	Group	Samples with mutation in group (%)	Non- synonymous Mutations (n=)	Synonymous Mutations (n=)	p-value	q-value
Overall
HIST1H1E	All	2.8	15	1	< 9×10−18	< 9×10−18
IRF4	All	3.2	15	1	< 9×10−18	< 9×10−18
KRAS	All	21.1	104	0	< 9×10−18	< 9×10−18
MAX	All	2.4	13	0	< 9×10−18	< 9×10−18
NRAS	All	19.4	91	0	< 9×10−18	< 9×10−18
TP53	All	3.0	16	0	< 9×10−18	< 9×10−18
TRAF3	All	3.7	19	0	< 9×10−18	< 9×10−18
FAM46C	All	5.6	26	1	5.00 ×10−15	1.05 ×10−11
DIS3	All	8.6	48	1	5.88 ×10−15	1.11 ×10−11
BRAF	All	6.7	36	0	8.77 ×10−15	1.50 ×10−11
LTB	All	3.0	14	1	2.84 ×10−8	4.46 ×10−5
CYLD	All	2.4	14	0	6.65 ×10−6	9.66 ×10−3
RB1	All	1.5	7	0	1.96 ×10−5	2.64 ×10−2
t(4;14)
DIS3	t(4;14)	25.4	18	0	7.05 ×10−8	1.33 ×10−3
FGFR3	t(4;14)	16.9	12	0	6.93 ×10−7	6.54 ×10−3
t(11;14)
KRAS	t(11;14)	33.7	31	0	< 9×10−18	< 9×10−18
NRAS	t(11;14)	25.6	22	0	1.44 ×10−15	1.36 ×10−11
DIS3	t(11;14)	11.6	12	0	5.74 ×10−6	3.61 ×10−2
IRF4	t(11;14)	10.5	9	0	1.18 ×10−5	5.57 ×10−2
Hyperdiploidy
KRAS	HRD	20.6	54	0	< 9×10−18	< 9×10−18
NRAS	HRD	24.4	53	0	< 9×10−18	< 9×10−18
FAM46C	HRD	7.1	15	1	6.99 ×10−9	4.40 ×10−5
BRAF	HRD	6.7	16	0	1.45 ×10−6	6.85 ×10−3
EGR1	HRD	4.6	11	1	4.65 ×10−6	1.70 ×10−2
CYLD	HRD	2.9	11	0	1.89 ×10−5	5.09 ×10−2