Table 2.

Prognostic impact of the main variables in myeloma. Median survivals for mutations, CNSA and clinical variables are summarised in this table. NS stands for nonsignificant. NR for not reached.

	PFS present (months)	PFS absent (months)	p value	2 year-OS present (%)	2 year-OS absent (%)	p value	Frequency (%)
Clinical features
Age>70	18.7	30.5	<0.0001	76%	81%	0.06	40%
Creatinine >150	18.7	27.7	0.0003	67%	81%	0.0009	12%
ISS I	39.1		-	87%		-	30%
ISS II	27.3		0.01	79%		0.13	29%
ISS III	22.0		<0.0001	74%		0.0004	34%
Mutations
ZFHX4	8.8	26.9	<0.0001	72%	80%	NS	4%
TP53	13.7	26.9	0.0005	27%	81%	0.0001	3%
ATM/ATR mutations	15.4	26.6	0.02	55%	81%	0.0008	4%
IRF4	Not reached	26.1	0.09	100%	79%	0.05	3.2%
EGR1	35.1	26.1	NS	100%	79%	0.04	3.5%
CCND1	10.7	26.6	NS	38%	80%	0.005	2.2%
NCKAP5	10.6	26.6	NS	53%	80%	0.04	2.2%
Translocations and copy number abnormalities
Del(17p)[TP53]	15	27.5	<0.0001	52%	82%	<0.0001	9.5%
t(4;14)	16.7	27.7	0.0001	71%	80%	0.08	12.7%
Del(13q)	22.7	28.7	0.0008	75%	82%	NS	42.1%
Normal 1q [CKS1B]	29.7		-	81%		-	61%
Gain(1q) [CKS1B]	26.1		NS	81%		NS	28%
Amp(1q) [CKS1B]	16.8		0.004	61%		0.0002	9.5%
Hyperdiploidy	29.6	23.7	0.009	81%	77%	NS	51.4%
MYC translocation	21.7	27.5	0.008	68%	82%	0.006	18.4%
Del(12p)	22.7	26.7	0.015	68%	80%	0.09	8.9%
MAF translocations	17.6	26.6	NS	65%	80%	NS	4.5%
Del(1p)[FAF1 CDKN2C]	21.7	26.7	NS	58%	81%	0.001	8.4%
t(14;16)	17.6	26.6	NS	69%	80%	NS	3.8%
Del(1p) [FAM46C]	26.6	26	NS	79%	79%	NS	24%
Del(16q)	27	25.8	NS	77%	81%	NS	18.6%
t(11;14)	26.6	26.1	NS	78%	79%	NS	18.6%
Del(14q32) [TRAF3]	26.9	26.3	NS	80%	79%	NS	13.2%
Pathways
TP53 signal *	15.4	28.4	<0.0001	46%	83%	<0.0001	11%
DIS3 signal *	22.1	28.5	0.001	77%	81%	NS	40.2%
FAM46C signal *	26.9	25.5	NS	79%	79%	NS	27%
RAS mutated	27.5	23.9	NS	80%	78%	NS	43%
FAF1 signal *	22.8	26.7	NS	62%	81%	0.001	9.9%
NF-κB signal *	25.5	26.6	NS	78%	81%	NS	37%

^*Signal refers to the combination of mutations and copy number changes