2. Adverse events (non‐severe).
| Study | Intervention | Comparison |
| Doxycycline | Tetracycline | |
| Brown 1978 | Vomiting (8/35) Rash (1/35) |
None reported |
| Song 1995 | Gastrointestinal reactions (33/66) | Gastrointestinal reactions (10/50) |
| Study | Doxycycline | Macrolides |
| Kim 2004 | Nausea (4/47) Diarrhoea (2/47) Abdominal discomfort (1/47) Raised ALT (5/47) Thrombocytopaenia (1/47) |
(Azithromycin) Nausea (6/46) Vomiting (3/46) Raised ALT (4/46) |
| Kim 2007 | Nausea (2/45) Vomiting (1/45) Diarrhoea (1/45) Abdominal discomfort (2/45) Elevated ALT (2/45) Skin rash (2/45) Oesophageal candidiasis (1/45) |
(Telithromycin) Abdominal discomfort (3/47) Elevated ALT (4/47) |
| Phimda 2007 | Nausea (3/145) Vomiting (22/145) Nausea and vomiting (10/145) Diarrhoea (1/145) Abdominal pain (1/145) Rash (1/145) Dizziness (1/145) |
(Azithromycin) Nausea (1/151) Vomiting (10/151) Nausea and vomiting (1/151) Diarrhoea (1/151) Rash (3/151) |
| Study | Doxycycline | Rifampicin |
| Watt 2000 | Rash and eosinophilia (1/28) "Severe gastrointestinal (GI) side effects" (2/28) "Mild GI side effects" (14/28) |
Rash and eosinophilia (7/50) "Mild GI side effects" (18/50) Red‐orange discolouration of urine (50/50) |
Abbreviations: ALT: alanine aminotransferase; GI: gastrointestinal.