Comparison 2. Macrolides versus doxycycline.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Treatment failure	3	242	Risk Ratio (M‐H, Fixed, 95% CI)	2.71 [0.12, 63.84]
2 Resolution of fever within 48 hours	2	150	Risk Ratio (M‐H, Random, 95% CI)	0.81 [0.32, 2.03]
3 Resolution of fever within 5 days	2	185	Risk Ratio (M‐H, Fixed, 95% CI)	1.05 [0.99, 1.10]
4 Serious adverse events	3	242	Risk Ratio (M‐H, Fixed, 95% CI)	0.0 [0.0, 0.0]