NCT00568711.

Trial name or title	Controlled Trial: 5‐Day Course of Rifampin Versus Doxycycline for the Treatment of Mild to Moderate Scrub Typhus
Methods	RCT
Participants	Inclusion criteria Adults 18 years of age or older Fever higher than 37.5˚C Concurrent presence of eschar or a maculopapular skin rash; and clear presence of more than 2 symptoms such as headache, malaise, myalgia, coughing, nausea, and abdominal discomfort Patients hospitalized between 2006 and 2009 at Chosun University Hospital in Gwangju, South Korea, or at one of its 2 community‐based affiliated hospitals, all of which are located in southwestern Korea Exclusion criteria Inability to take oral medications Pregnancy Hypersensitivity to trial drugs Previous drug therapy with potential anti‐rickettsial activity (for example, rifampicin, chloramphenicol, macrolides, fluoroquinolones, tetracyclines) within 48 hours before admission Severe scrub typhus (shock requiring vasopressor therapy for longer than 1 hour) Stuporous or comatose level of consciousness Respiratory failure requiring mechanical ventilation or renal failure requiring immediate dialysis For the differential diagnosis of scrub typhus from other diseases with similar symptoms (for example, murine typhus, leptospirosis, haemorrhagic fever with renal syndrome, systemic lupus erythematosus), patients underwent diagnostic tests. We thus excluded patients with concurrent infections at risk for causing different outcomes
Interventions	5‐day rifampin therapy 5‐day doxycycline therapy
Outcomes	Fever clearance time Cure Failure Relapse
Starting date	September 2006 Expected completion: December 2009 Unknown recruitment status
Contact information	Prof. Dong‐Min Kim drongkim@chosun.ac.kr; Chosun University Hospital, Kwangju, Jeollanamdo, South Korea
Notes	Location: Chosun University Hospital, or one of its 2 community‐based affiliated hospitals, all of which are located in southwestern Korea Study ID number: NCT00568711