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. Author manuscript; available in PMC: 2019 Apr 26.
Published in final edited form as: Nat Methods. 2014 Aug 31;11(10):1064–1070. doi: 10.1038/nmeth.3092

Figure 3.

Figure 3

Distribution of cross-linking sites in identified RNA-binding proteins with annotated domain structure. The panels show (a) human proteins, (b) yeast proteins isolated with TAP tagged Cbp20, (c) yeast proteins cross-linked to 4-thio-U and isolated with oligo d(T). Ribosomal proteins are not included. Proteins are represented by their corresponding gene names to avoid ambiguity. (Putative) RNA-/DNA-binding domains, nucleotide binding sites, and active/substrate binding sites are given if annotated in protein databases. All appearing domains and sites are listed on the lower right with their assigned symbols. Information is derived from the UniProt database and supplemented with details from NCBI, Pfam, Superfamily, and CATH (Supplementary Tables 1–3). Yeast gene VMA1 encodes for V-type proton ATPase catalytic subunit A and Endonuclease PI-Scel, only the latter is shown since it contains the cross-linked regions.