| Study ID |
Progression |
Response |
| Hjorth 1993 |
Increasing serum M protein IgG>50g/l, IgA>30g/l, or Bence Jones proteinuria >4g/l, bone pains and osteolytic bone lesions or hypercalcemia, anemia or rising serum creatinine |
Reduction in M protein of >50% |
| Riccardi 1994 |
>25% increase in MC (mono‐clonal component) and/or an increase in BMPC (bone marrow plasma cell) of at least 20% and/or worsening of laboratory parameters (hemoglobin, serum calcium, and blood urea nitrogen) and/or of skeletal lytic lesions |
Reduction in MC, drop in BMPC of <20%, 2g/dl rise in Hb, normal serum calcium, serum albumin >3g/dl |
| Riccardi 2000 |
Increase in MC, appearance/enlargement of bone lesions, anemia (Hb<10g/dl), hypercalcemia, renal failure |
Reduction in MC, drop in BMPC of <20%, 2g/dl rise in Hb, normal serum calcium, serum albumin >3g/dl |
