Comparison 1. Outcome.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Mortality	3	262	Peto Odds Ratio (95% CI)	1.11 [0.67, 1.84]
2 Progression	2	212	Peto Odds Ratio (95% CI)	0.16 [0.09, 0.29]
3 Response	2	156	Odds Ratio (M‐H, Fixed, 95% CI)	0.63 [0.33, 1.23]
4 Vertebral compression	2	188	Odds Ratio (M‐H, Fixed, 95% CI)	0.18 [0.02, 1.59]
5 Acute leukemia	3	262	Peto Odds Ratio (95% CI)	3.20 [0.55, 18.72]