| Methods |
RCT
ITT‐No
Jadad=3
Power analysis not described
Duration of follow‐up: 6 yr |
| Participants |
Stage I MM
Durie and Salmon
Early treatment:
Enrolled 75, analyzed 72;
Deferred treatment:
Enrolled 70,
analyzed 66
(all patients evaluable for response) |
| Interventions |
MPH: 0.21mg/kg
4 days,
P: 0.5 mg/kg
10 days,
6 week intervals |
| Outcomes |
Mortality
Progression
Response
Osteolysis
Hypercalcemia
Vertebral compression
Renal insufficiency
Leukemia |
| Notes |
Not double‐blind
Withdrawls and dropouts described |
| Risk of bias |
| Bias |
Authors' judgement |
Support for judgement |
| Allocation concealment (selection bias) |
Low risk |
A ‐ Adequate |
