Table 4. MHCI tetramer staining: association rates.
ligand | λslow (min−1) | λfast (min−1) | capture effect |
λeff(∞) (min−1) | |||
---|---|---|---|---|---|---|---|
|
|
||||||
wild-type | CD8-null | wild-type | CD8-null | wild-type | CD8-null | ||
3G | 0.18 | 0.07 | 3.08 | 4.01 | 61% | 1.53 | 0.76 |
8Y | 0.12 | 0.13 | 3.07 | 4.45 | 85% | 1.30 | 1.25 |
8T | 0.14 | 0.13 | 8.10 | 7.81 | 90% | 3.11 | 2.34 |
wild-type: hla-a2; CD8-null: hla-a2 DT227/8KA capture effect: calculated decrease of recruitment rate ψ in CD8-null data from Laugel et al. (2007)