Drug	Dose (mg)	Number of		Number with outcome/total		Percent with outcome		Risk ratio (95% CI)	NNT (95% CI)
		Studies	Participants	Active	Placebo	Active	Placebo
Aspirin	500	2	213	45/135	20/78	34	26	1.3 (0.8 to 2.0)	Not calculated
Aspirin	600/650	60	4965	983/2496	379/2469	39	15	2.5 (2.3 to 2.8)	4.2 (3.8 to 4.6)
Aspirin	1000	6	618	138/340	40/278	41	14	2.7 (2.0 to 3.7)	4.2 (3.8 to 4.6)
Dexketoprofen	12.5	5	452	104/230	38/222	45	17	2.7 (2.0 to 3.7)	3.6 (2.8 to 5.0)
Dexketoprofen	25	6	523	129/225	38/248	47	15	3.3 (2.4 to 4.5)	3.2 (2.6 to 4.1)
Diclofenac potassium	25	4	502	140/248	37/274	56	15	3.9 (2.8 to 5.3)	2.4 (2.0 to 2.9)
Diclofenac potassium	50	7	757	253/398	60/359	64	17	3.7 (2.9 to 4.7)	2.1 (1.9 to 2.5)
Dipyrone	500	5	288	106/143	45/145	74	31	2.4 (1.8 to 3.1)	2.3 (1.9 to 3.1)
Ibuprofen acid	200	18	2103	448/1094	67/1009	41	7	6.5 (5.1 to 8.2)	2.9 (2.7 to 3.2)
Ibuprofen acid	400	51	5604	1596/3070	289/2543	52	12	4.6 (4.0 to 5.1)	2.5 (2.4 to 2.6)
Ibuprofen fast acting	200	7	828	270/478	34/350	57	10	5.7 (4.2 to 7.9)	2.1 (1.9 to 2.4)
Ibuprofen fast acting	400	13	1364	427/658	85/466	65	18	3.9 (3.2 to 4.7)	2.1 (1.9 to 2.3)
Ibuprofen + caffeine	200+100	4	334	103/174	16/160	59	10	5.5 (3.5 to 8.7)	2.1 (1.9 to 3.1)
Ibuprofen + paracetamol	200+500	3	508	240/349	10/159	69	6	10 (5.7 to 19)	1.6 (1.5 to 1.8)
Ibuprofen + paracetamol	400+1000	3	543	278/384	10/159	72	6	11 (6.2 to 20)	1.5 (1.4 to 1.7)
Naproxen	200/220	2	202	54/120	16/82	45	30	2.9 (1.6 to 5.1)	3.4 (2.4 to 5.8)
Naproxen	400/440	3	334	103/210	14/124	49	11	4.8 (2.8 to 8.4)	2.7 (2.2 to 3.5)
Naproxen	500/550	9	784	200/394	59/390	52	15	3.4 (2.6 to 4.4)	2.7 (2.3 to 3.3)
Paracetamol	500	6	561	176/290	86/271	61	32	1.9 (1.6 to 2.3)	3.5 (2.7 to 4.8)
Paracetamol	600/650	19	1886	358/954	145/932	38	16	2.4 (2.0 to 2.8)	4.6 (3.9 to 5.5)
Paracetamol	975/1000	28	3232	876/1906	241/1329	46	18	2.7 (2.4 to 3.0)	3.6 (3.2 to 4.1)
CI: confidence interval; NNT: number needed to treat for an additional beneficial outcome. Note: NNT not calculated when result not significantly different from placebo.