1. Risk of bias (adverse events).

Study	Risk of bias	Did the researchers actively monitor for AEs or did they simply provide spontaneous reporting of AEs that arose?	Risk of bias	Did the authors define SAEs according to an accepted international classification and report the number of SAEs?
Chen 2006	Unclear	Information not provided.	Unclear	Information not provided.
Rayamajhi 2015	Low	The authors reported that participants were monitored for AEs from first day of commencing treatment until death or discharge	Low	AEs graded using WHO recommendations and reported to an independent data safety monitoring committee. Information recorded on standardised proformas.
Wu 2014	Unclear	Information not provided.	Unclear	Information not provided.

AE: adverse events; SAE: serious adverse events; WHO: World Health Organisation.