Source	Search strategy
CENTRAL (the Cochrane Library) (2016, Issue 9)	#1 encephalitis:ti,ab,kw (Word variations have been searched) #2 meningoencephalitis:ti,ab,kw (Word variations have been searched) #3 ((brain or cerebral) near/2 (infection* or infectious or inflamm* or swell*)):ti,ab,kw (Word variations have been searched) #4 #1 or #2 or #3 #5 MeSH descriptor: [Immunoglobulins, Intravenous] explode all trees #6 ((intravenous or intra‐venous) near/3 immunoglobulin*):ti,ab,kw (Word variations have been searched) #7 ivig or igiv:ti,ab,kw (Word variations have been searched) #8 immunoglobulin* or immunotherap*:ti (Word variations have been searched) #9 #5 or #6 or #7 or #8 #10 #4 and #9
MEDLINE (PubMed) (1966 to 30 September 2016)	1 exp Encephalitis/ 2 encephalitis.ti,ab. 3 meningoencephalitis.ti,ab. 4 ((brain or cerebral) adj2 (infection* or infectious or inflamm* or swell*)).ti,ab. 5 1 or 2 or 3 or 4 6 adolescent/ or exp child/ or infant/ or infant, newborn/ 7 (child* or preschool* or pre‐school* or schoolchild* or infant* or infancy or baby or babies or toddler* or teen* or adolescen* or youth*).ti,ab. 8 6 or 7 9 Immunoglobulins, Intravenous/ 10 ((intravenous or intra‐venous) adj3 immunoglobulin*).ti,ab. 11 (ivig or igiv).ti,ab. 12 (immunoglobulin* or immunotherap*).ti. 13 9 or 10 or 11 or 12 14 5 and 8 and 13 15 limit 14 to "reviews (maximizes specificity)" 16 randomised controlled trial.pt. 17 controlled clinical trial.pt. 18 randomized.ab. 19 placebo.ab. 20 drug therapy.fs. 21 randomly.ab. 22 trial.ab. 23 groups.ab. 24 16 or 17 or 18 or 19 or 20 or 21 or 22 or 23 25 exp animals/ not humans.sh. 26 24 not 25 27 14 and 26
Embase (embase.com) (1974 to 30 September 2016)	1 exp *Encephalitis/ 2 encephalitis.ti,ab. 3 meningoencephalitis.ti,ab. 4 ((brain or cerebral) adj2 (infection* or infectious or inflamm* or swell*)).ti,ab. 5 1 or 2 or 3 or 4 6 adolescent/ or child/ or boy/ or girl/ or infant/ or preschool child/ or school child/ or toddler/ 7 (child* or preschool* or pre‐school* or schoolchild* or infant* or infancy or baby or babies or toddler* or teen* or adolescen* or youth*).ti,ab. 8 6 or 7 9 exp *immunoglobulin/ and intravenous drug administration/ 10 exp *immunoglobulin/iv [Intravenous Drug Administration] 11 ((intravenous or intra‐venous) adj3 immunoglobulin*).ti,ab. 12 (ivig or igiv).ti,ab. 13 (immunoglobulin* or immunotherap*).ti. 14 9 or 10 or 11 or 12 or 13 15 5 and 8 and 14 16 limit 15 to "reviews (maximizes specificity)" 17 randomised controlled trial/ 18 controlled clinical trial/ 19 single blind procedure/ or double blind procedure/ 20 crossover procedure/ 21 random*.tw. 22 placebo*.tw. 23 ((singl* or doubl*) adj (blind* or mask*)).tw. 24 (crossover or cross over or factorial* or latin square).tw. 25 (assign* or allocat* or volunteer*).tw. 26 17 or 18 or 19 or 20 or 21 or 22 or 23 or 24 or 25
CINAHL (EBSCO host) (1981 to 30 September 2016)	S1 AB randomised controlled trial or controlled clinical trial or randomized or placebo or drug therapy or randomly or trial or groups S2 AB inflamm* or swell* or infection* or infectious or Immunoglobulins, Intravenous or intravenous or intra‐venous or immunoglobulin* or ivig or igiv or immunoglobulin* or immunotherap* S3 MH Encephalitis OR AB ( encephalitis or meningoencephalitis ) S4 S2 OR S3 S5 S1 AND S4 S6 AB randomised controlled trial or controlled clinical trial or randomized or placebo or drug therapy or randomly or trial or groups Limiters ‐ Age Groups: Infant, Newborn: birth‐1 month, Infant: 1‐23 months, Child, Preschool: 2‐5 years, Child: 6‐12 years, Adolescent: 13‐18 years
ClinicalTrials.gov (www.clinicaltrials.gov)	(encephalitis OR meningoencephalitis) AND (immunoglobulin OR immunoglobulins OR ivig OR igiv OR immunotherapy)
ICTRP Search Portal (apps.who.int/trialsearch)	(encephalitis OR meningoencephalitis) AND (immunoglobulin OR immunoglobulins OR ivig OR igiv OR immunotherapy)
Science Citation Index Expanded (SCI‐EXPANDED) & Conference Proceedings Citation Index‐ Science (CPCI‐S) (Web of Science Core Collection, Thomson Reuters) (1945 to 30 September 2016)	# 1 TOPIC: (encephalitis OR meningoencephalitis) OR TOPIC: (((brain or cerebral) NEAR/2 (infection* or infectious or inflamm* or swell*))) # 2 TOPIC: (child* or preschool* or pre‐school* or schoolchild* or infant* or infancy or baby or babies or toddler* or teen* or adolescen* or youth*) # 3 TOPIC: (((intravenous or intra‐venous) NEAR/3 immunoglobulin*)) OR TOPIC: (ivig or igiv) OR TITLE: (immunoglobulin* or immunotherap*) # 4 #3 AND #2 AND #1 # 5 TOPIC: (random* or blind* or allocat* or assign* or trial* or placebo* or crossover* or cross‐over*) # 6 #5 AND #4
Global Health Library (Virtual Health Library) (www.globalhealthlibrary.net/php/index.php)	(encephalitis OR meningoencephalitis) AND (immunoglobulin OR immunoglobulins OR ivig OR igiv OR immunotherapy)
Database of Abstracts of Reviews of Effects (DARE)	(encephalitis OR meningoencephalitis) AND (immunoglobulin OR immunoglobulins OR ivig OR igiv OR immunotherapy)