Date	Event	Description
18 September 2017	New search has been performed	A search of the Cochrane Cystic Fibrosis and Genetic Disorder's Group's Inborn Errors of Metabolism Regiter identified 36 references, none of which were eligible for inclusion in the review.
18 September 2017	New citation required but conclusions have not changed	Minor changes have been made throughout the review.
11 July 2012	Review declared as stable	This review will no longer be regularly updated. Searches will still be undertaken on a two‐yearly basis by the Cochrane Cystic Fibrosis & Genetic Disorders Group. If, in future, relevant trials are identified, the review will be updated again.
10 May 2012	New citation required but conclusions have not changed	New searches have been carried out but no changes have been made to the conclusions.
10 May 2012	New search has been performed	A search of the Group's Inborn Errors of Metabolism Register identified three references which have all been listed in Excluded studies (Gonzales 2010; Kishnani 2009; Zimran 2011). New searches of the websites: www.clinicaltrials.gov; www.genzymeclinicalresearch.com, did not identify any trials eligible for inclusion in the review.
4 June 2010	New search has been performed	New searches have been carried out, resulting in no significant changes to the review. Four trials have been added to Excluded studies (Almon 2008; Mehta 2008; Schiffmann 2008; Weinreb 2008).
12 August 2009	Amended	Contact details updated.
7 May 2008	Amended	Converted to new review format.