Suske 1996.
Methods | Randomised controlled trial | |
Participants | 26 preterm infants < 2 hours old, with birth weight < 1500 grams if FiO2 > 0.50, or > 1500 grams birth weight with FiO2 > 0.70 Exclusions: known sepsis, cardiac anomalies, malformations of lung or CNS |
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Interventions | Intravenous dexamethasone 0.5 mg/kg/d for 5 days Controls were not given placebo. | |
Outcomes | Blood gases, ventilator settings, mortality IVH, BPD (O2 28 days), NEC, late sepsis, PDA, ROP, air leak, duration in hospital | |
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Random allocation via sealed envelopes. Randomisation achieved by drawing lots |
Allocation concealment (selection bias) | Low risk | Allocation concealment: yes |
Blinding of participants and personnel (performance bias) All outcomes | High risk | Blinding of intervention: no |
Blinding of outcome assessment (detection bias) All outcomes | High risk | Blinding of outcome measurement: no |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Complete follow‐up: yes |
Selective reporting (reporting bias) | Low risk | All prespecified outcomes reported |