Table 3.
Top 10 genes upregulated and downregulated by 5 days of bed rest
| Young |
Old |
||||
|---|---|---|---|---|---|
| Gene name | Fold change | Adjusted P value | Gene name | Fold change | Adjusted P value |
| Upregulated | |||||
| ATP1A4 | 3.77 | 2.54E-04 | PFKFB3 | 3.34 | 9.34E-09 |
| RP11-680G24.4 | 2.99 | 2.22E-03 | RP11-369K17.1 | 3.00 | 1.27E-05 |
| FASN | 2.88 | 8.19E-03 | PNPLA3 | 2.89 | 2.45E-02 |
| MYH1 | 2.80 | 3.66E-02 | CPXM1 | 2.87 | 1.19E-02 |
| PFKFB3 | 2.79 | 2.36E-03 | KRT17P4 | 2.76 | 1.04E-02 |
| RPS4XP5 | 2.78 | 1.68E-04 | TMEM63C | 2.69 | 5.85E-03 |
| UNQ6494 | 2.66 | 1.69E-02 | TMEM215 | 2.56 | 1.15E-02 |
| USP6 | 2.53 | 2.21E-08 | HAS2-AS1 | 2.46 | 5.69E-03 |
| PDE11A | 2.44 | 8.36E-05 | RGMB-AS1 | 2.40 | 1.52E-02 |
| CTD-2095E4.3 | 2.43 | 2.43E-03 | CXCL2 | 2.39 | 4.33E-03 |
| Downregulated | |||||
| SLC26A9 | 0.14 | 2.29E-04 | RP11-145A3.1 | 0.09 | 9.12E-21 |
| RP11-145A3.1 | 0.18 | 6.18E-05 | LRRC52 | 0.17 | 2.12E-04 |
| THY1 | 0.23 | 5.35E-09 | SLC26A9 | 0.19 | 2.47E-06 |
| TNFRSF12A | 0.23 | 5.56E-04 | LBP | 0.20 | 3.19E-07 |
| HMGCS2 | 0.23 | 2.05E-03 | ADAMTS8 | 0.22 | 1.55E-09 |
| NOV | 0.27 | 7.69E-07 | ABCC12 | 0.24 | 3.50E-12 |
| LBP | 0.30 | 3.83E-02 | METTL21C | 0.25 | 1.52E-06 |
| TNC | 0.31 | 2.07E-02 | SEL1L2 | 0.26 | 4.05E-05 |
| APLN | 0.31 | 4.36E-05 | SLC5A1 | 0.27 | 1.75E-03 |
| MYL12A | 0.31 | 2.96E-11 | MUC22 | 0.28 | 5.09E-04 |
Genes are ordered by fold change.