. 2019 Jan 3;126(4):894–902. doi: 10.1152/japplphysiol.00811.2018

Table 4.

Genes altered by bed rest in Old subjects that correlate with change in leg lean mass

				LLM Correlation
Ensembl ID	Gene Name	Biotype	Ensembl Description	R² coefficient	P value
ENSG00000155761	SPAG17	Protein_coding	Sperm associated antigen 17	0.297	0.003
ENSG00000110906	KCTD10	Protein_coding	Potassium channel tetramerization domain containing 10	0.265	0.006
ENSG00000276791	CTD-2270P14.5	lincRNA		0.264	0.006
ENSG00000204103	MAFB	Protein_coding	MAF bZIP transcription factor B	0.246	0.009
ENSG00000137834	SMAD6	Protein_coding	SMAD family member 6	0.231	0.011
ENSG00000113296	THBS4^*	Protein_coding	Thrombospondin 4	0.230^*	0.013^*
ENSG00000157538	DSCR3	Protein_coding	DSCR3 arrestin fold containing	0.216	0.015
ENSG00000129991	TNNI3	Protein_coding	Troponin I3, cardiac type	0.207	0.017
ENSG00000135469	COQ10A	Protein_coding	Coenzyme Q10A	0.205	0.018
ENSG00000180447	GAS1	Protein_coding	Growth arrest specific 1	0.201	0.019
ENSG00000100281	HMGXB4	Protein_coding	HMG-box containing 4	0.199	0.020
ENSG00000169436	COL22A1	Protein_coding	Collagen type XXII α1 chain	0.199	0.020
ENSG00000182809	CRIP2	Protein_coding	Cysteine rich protein 2	0.187	0.024
ENSG00000134243	SORT1	Protein_coding	Sortilin 1	0.180	0.027
ENSG00000118298	CA14	Protein_coding	Carbonic anhydrase 14	0.180	0.027
ENSG00000154767	XPC	Protein_coding	XPC complex subunit, DNA damage recognition and repair factor	0.174	0.030
ENSG00000113273	ARSB	Protein_coding	Arylsulfatase B	0.165	0.035
ENSG00000042445	RETSAT	Protein_coding	Retinol saturase	0.163	0.037
ENSG00000261326	LINC01355	lincRNA	Long intergenic nonprotein coding RNA 1355	0.162	0.037
ENSG00000166797	FAM96A	Protein_coding	Family with sequence similarity 96 member A	0.161	0.038
ENSG00000156463	SH3RF2	Protein_coding	SH3 domain containing ring finger 2	0.159	0.040
ENSG00000255874	LINC00346	lincRNA	Long intergenic nonprotein coding RNA 346	0.158	0.040
ENSG00000166148	AVPR1A	Protein_coding	Arginine vasopressin receptor 1A	0.149	0.047
ENSG00000151458	ANKRD50	Protein_coding	Ankyrin repeat domain 50	0.148	0.048
ENSG00000163807	KIAA1143	Protein_coding	KIAA1143	0.148	0.048
ENSG00000166780	C16orf45	Protein_coding	Chromosome 16 open reading frame 45	0.147	0.048
ENSG00000248309	MEF2C-AS1	Antisense	MEF2C antisense RNA 1	0.147	0.048
ENSG00000119669	IRF2BPL	Protein_coding	Interferon regulatory factor 2 binding protein like	0.146	0.049
ENSG00000162377	COA7	Protein_coding	Cytochrome-c oxidase assembly factor 7 (putative)	0.146	0.049
ENSG00000163596	ICA1L	Protein_coding	Islet cell autoantigen 1 like	0.145	0.050

n = 9 Young, 18 Old. Statistical design included age + age:nested + age:time. Fold changes were determined with maximum-likelihood estimates of the log₂ fold change. lincRNA, long intergenic noncoding RNA LLM, leg lean mass. An adjusted P value of P < 0.05 was required for a gene to be considered significantly altered.

One outlier removed from Young.