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. 2014 Dec 11;2014(12):CD009281. doi: 10.1002/14651858.CD009281.pub3

Forbes 1990.

Methods Multicentre, randomised, double‐blind, placebo‐controlled, parallel‐group study, with a single oral dose administered at the onset of steady moderate or severe pain
Duration: 6 h, with assessments at baseline, 1, 2, 3, 4, 5, and 6 h post dose
Participants Dental surgery: third molar removal
Patients were ≥ 15 years of age
N = 401 (350 for efficacy)
M 147, F 203
Mean age 21 years
Interventions Aspirin 650 mg + caffeine 65 mg, n = 66 for efficacy
Aspirin 650 mg, n = 68 for efficacy
Aspirin 1000 mg, n = 71 for efficacy
Caffeine 65 mg, n = 70 for efficacy
Placebo, n = 75 for efficacy
Outcomes PI: standard 4‐point scale
PR: standard 5‐point scale
PGE: standard 5‐point scale
Withdrawals and dropouts
Serious adverse events
Notes Oxford Quality Score: R2, DB2, W1. Total = 5/5
Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Low risk Computer‐generated randomisation schedule
Allocation concealment (selection bias) Unclear risk Method not described
Blinding of participants and personnel (performance bias) 
 All outcomes Low risk "all tablets were identical in appearance"
Size Unclear risk 50 to 200 participants in relevant treatment arms