NCT01929031.

Methods	Randomised, double‐blind, placebo‐controlled, parallel‐group study Single and multiple dose phases
Participants	Third molar extraction (3 to 4 molars, ≥ 2 mandibular) N = 561 Age 18 to 55 years M and F Pain intensity moderate (≥ 5/10)
Interventions	Ibuprofen 400 mg + caffeine 100 mg Ibuprofen 400 mg Caffeine 100 mg Placebo
Outcomes	SPRID 0 to 2 h Time to rescue medication
Notes	Completed; estimated final collection date for primary outcome March 2014 Sponsor: Boehringer Ingelheim