Comparison 1. Ocriplasmin versus sham injection.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Complete release of vitreous adhesion 28 days after treatment	4	859	Risk Ratio (M‐H, Random, 95% CI)	3.46 [2.00, 6.00]
2 Closure of macular hole 28 days after treatment	3	229	Risk Ratio (M‐H, Random, 95% CI)	2.87 [1.50, 5.51]
3 Complete posterior vitreous detachment 28 days after treatment	3	689	Risk Ratio (M‐H, Random, 95% CI)	2.94 [1.39, 6.24]
4 > 3‐line improvement in BCVA 6 months after treatment	3	674	Risk Ratio (M‐H, Random, 95% CI)	1.95 [1.07, 3.53]
5 Requirement for pars plana vitrectomy at month 6	3	689	Risk Ratio (M‐H, Random, 95% CI)	0.67 [0.50, 0.91]
6 Any ocular adverse event	4	909	Risk Ratio (M‐H, Random, 95% CI)	1.22 [1.09, 1.37]