Mandatory items		Optional items
Methods
Study design	Parallel group RCT i.e. people randomised to treatment Within‐person RCT i.e. eyes randomised to treatment Cluster RCT i.e. communities randomised to treatment Cross‐over RCT Other, specify	Exclusions after randomisation Losses to follow‐up Number randomised/analysed How were missing data handled? e.g. available case analysis, imputation methods Reported power calculation (Y/N), if yes, sample size and power Unusual study design/issues
Eyes or Unit of randomisation/unit of analysis	1 eye included in study, specify how eye selected 2 eyes included in study, both eyes received same treatment, briefly specify how analysed (best/worst/mean/both and adjusted for within‐person correlation/both and not adjusted for within‐person correlation) and specify if mixture 1 eye and 2 eyes 2 eyes included in study, eyes received different treatments, specify if correct pair‐matched analysis done
Participants
Country		Setting Ethnic group Equivalence of baseline characteristics (Y/N)
Total number of participants	This information should be collected for total study population recruited into the study. If these data are only reported for the people who were followed up only, please indicate.
Number (%) of men and women
Mean age and age range
Inclusion criteria
Exclusion criteria
Interventions
Intervention (n = ) Comparator (n = ) See MECIR 65 and 70	Number of people randomised to this group Drug (or intervention) name Dose Frequency Route of administration
Outcomes
Primary and secondary outcomes as defined in study reports See MECIR R70	List outcomes Adverse events reported (Y/N) Length of follow‐up and intervals at which outcomes assessed	Planned/actual length of follow‐up
Notes
Date conducted	Specify dates of recruitment of participants mm/yr to mm/yr	Full study name:(if applicable) Reported subgroup analyses (Y/N) Were trial investigators contacted?
Sources of funding
Declaration of interest See MECIR 69