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. 2019 Feb 6;121(4):1232–1243. doi: 10.1152/jn.00448.2018

Fig. 1.

Fig. 1.

Schematic of inner retinal circuitry connections to OFF bipolar cells with dopaminergic receptors. A: dim-light conditions activate the rod pathway [black cells; rod photoreceptors (R)-rod bipolar cells (RB)-AII amacrine cells]. Glycinergic AII amacrine cells inhibit OFF cone bipolar cells (OFF) and are coupled to other AII amacrine cells. Bright-light conditions activate the cone pathway [white cells; cone photoreceptors (C)-OFF and ON cone (ON) bipolar cells-wide-field GABAergic (GBA) and narrow-field glycinergic (Gly) amacrine cells-inhibitory connections to OFF bipolar cells]. OFF bipolar cells bridge rod and cone circuits and activate OFF ganglion cells (GC). Dopaminergic amacrine cells (DA) have wide-field processes that activate dopamine D1 receptors on bipolar, horizontal (HC), and amacrine cells. INL, inner nuclear layer; IPL, inner plexiform layer. B: light adaptation increases (Inc.) dopamine release and decreases (Dec.) local inhibition to OFF bipolar cells, but it is unknown how dopamine release that activates dopamine receptors affects OFF bipolar cell inhibition. C: cartoons showing measurements of the peak amplitude, charge transfer, and transience of a light-evoked inhibitory postsynaptic current (L-IPSC) and the peak amplitude (PA) and frequency (Freq.) of spontaneous inhibitory postsynaptic currents (sIPSCs; inset). #, Number of.