Fig. 4.

Dopamine D1 receptor activation reduces GABAergic spontaneous frequency but not peak amplitude. A: example GABAergic spontaneous inhibitory postsynaptic current (sIPSC) traces in dark-adapted conditions before (black) and after SKF38393 (SKF) application (dark gray). B: example GABAergic sIPSC peak amplitude histogram, normalized (Norm.) to number of events, of the cell in A. Arrows show the average peak amplitude. C: same conditions as B for example GABAergic sIPSC interevent intervals of the cell seen in A. D: average sIPSC peak amplitude and frequency, normalized to the dark-adapted condition, with SKF application (n = 4). Brackets indicate comparison with the dark-adapted condition (dotted line). Error bars are ±SE, and significance was calculated with the Wilcoxon rank sum test (*P < 0.05 and ***P < 0.001).