Fig. 6.

Dopamine D1 receptor activation reduces glycinergic spontaneous activity to light-adapted levels. A: example glycinergic spontaneous inhibitory postsynaptic current (sIPSC) traces in dark-adapted conditions before (black) and after SKF38393 (SKF) application (dark gray). B: example glycinergic sIPSC peak amplitude histogram, normalized (Norm.) to number of events, of the cell in A. Arrows show the average peak amplitude. C: same conditions as B for example glycinergic sIPSC interevent intervals of the cell seen in A. D: average peak amplitude in dark-adapted and SKF conditions (n = 5). E: example glycinergic sIPSC traces in dark- (black) and light-adapted (light gray) conditions. F: average peak amplitude, normalized to the dark-adapted condition, compared between SKF (n = 5) and light-adapted (n = 6) conditions. Brackets indicate comparison with the dark-adapted condition (dotted line). G: same conditions as F for average frequency compared between SKF (n = 5) and light-adapted (n = 6) conditions. H: average peak amplitude and frequency of glycinergic miniature (m)IPSCs with SKF application normalized to the dark-adapted condition (n = 7). Top inset shows example mIPSCs. Error bars are ±SE, and significance was calculated with the Wilcoxon rank sum test (*P < 0.05, **P < 0.01, ***P < 0.001).