Table 1.
Inhibition | Dark-Adapted, pA | +SKF, pA | Dark-Adapted, pA | Light-Adapted, pA | Dark-Adapted, Hz | +SKF, Hz | Dark-Adapted, Hz | Light-Adapted, Hz |
---|---|---|---|---|---|---|---|---|
Total inhibition | 26.9 ± 5.5 | 17.5 ± 4.6* | 23.2 ± 3.8 | 17.1 ± 2.3* | 11.5 ± 5.8 | 3.2 ± 1.6* | 17.0 ± 5.5 | 10.4 ± 3.4* |
Isolated GABA | 9.4 ± 1.3 | 9.4 ± 1.2 | 7.8 ± 1.2 | 0 ± 0 | 5.5 ± 4.3 | 0.8 ± 0.4* | 0.7 ± 0.5 | 0 ± 0 |
Isolated glycine | 21.4 ± 4.7 | 9.8 ± 1.8* | 23.0 ± 5.3 | 17.9 ± 3.6* | 9.3 ± 4.9 | 6.0 ± 3.6* | 16.5 ± 7.3 | 13.3 ± 5.9* |
Isolated glycine mIPSC | 8.4 ± 1.9 | 7.5 ± 1.7 | n.m. | n.m. | 3.3 ± 1.8 | 2.7 ± 1.7* | n.m. | n.m. |
Values are means ± SE. There were no significant differences between dark-adapted averages of SKF38393 (SKF) and light adaptation experiments. Italics indicate raw data that were adapted from Mazade and Eggers (2013) and used to compare SKF and light-adapted conditions. Value of 0 means that all spontaneous inhibitory postsynaptic currents (sIPSCs) were abolished in the given condition.
Values that are significantly different when normalized to dark-adapted values for each cell (Wilcoxon tests). Exact P values are given in the text. mIPSC, miniature inhibitory postsynaptic current; n.m., not measured.