Table 5. Top 10 upstream regulators of genes also regulated by Pgrmc1 in N42 hypothalamic cells.
Regulators shown in boldface type are steroids, steroid receptors or molecules known to regulate steroid synthesis or activities. Those shown in italic boldface are known to be regulated by Pgrmc1 or P4.
| Upstream Regulator | Direction of Change | Symbol | Molecule Type | P-Value of Overlap |
|---|---|---|---|---|
| β-Estradiol | Activated | E2 | Steroid transcription regulator | 2.94E-14 |
| E2F transcription factor 8 | E2f8 | Transcription regulator | 6.94E-10 | |
| Sterol regulatory element binding factor (Srebf) cleavage-activating protein | Activated | Scap | Chaperone protein | 8.38E-09 |
| Transforming growth factor β1 | Activated | Tgfβ1 | Cytokine; growth factor | 1.42E-08 |
| Huntington | Htt | Transcription regulator | 1.92E-07 | |
| Sterol regulatory element binding factor | Activated | Srebf2 | Transcription regulator | 3.04E-07 |
| E2F7 transcription factor 7 | E2f7 | Transcription regulator | 5.99E-07 | |
| Brain-derived neurotrophic factor | Activated | Bdnf | Nerve growth factor | 1.48E-06 |
| Estrogen receptor 1 (encodes estrogen receptor α) | Activated | Esr1 | Steroid transcription regulator | 3.39E-06 |
| Harvey rat sarcoma viral oncogene homolog | Hras | Ras oncogene | 3.73E-06 |