8. Any adverse event with opioids (from studies with or without comparators).

Review	Events	Total	Event rate (%)
			Average	95% CI
Cepeda 2006	481	1613	29.8	27.6 to 32.1
da Costa 2014	2145	2725	78.7	77.2 to 80.3
Enthoven 2016	454	785	57.8	54.4 to 61.3
Gaskell 2016	40	48	83.3	72.8 to 93.9
Rubinstein 2011	1	17	5.9	‐5.3 to 17.1
Santos 2015	766	894	85.7	83.4 to 88
Stannard 2016	21	43	48.8	33.9 to 63.8
Total events	3908	6622	59.0	57.8 to 60.2

CI: confidence interval