13. GRADE quality judgement: opioids versus placebo, specific adverse events.
|
Participants (reviews) |
Risk of bias | Inconsistency | Indirectness | Imprecision | Other considerations | Overall quality of evidence | |
| Constipation | 4255 (4 reviews) |
Serious | Not serious | Serious | Not serious | Strong association | +++◯ MODERATE |
| Dizziness | 4130 (4 reviews) |
Serious | Not serious | Serious | Not serious | Strong association | +++◯ MODERATE |
| Drowsiness or somnolence | 3856 (3 reviews) |
Serious | Not serious | Serious | Not serious | Strong association | +++◯ MODERATE |
| Fatigue | 1589 (1 review) |
Serious | Not serious | Very serious | Not serious | None | +◯◯◯ VERY LOW |
| Hot flushes | 593 (1 review) |
Serious | Not serious | Very serious | Not serious | None | +◯◯◯ VERY LOW |
| Increased sweating | 1350 (1 review) |
Serious | Not serious | Very serious | Not serious | Very strong association | +++◯ MODERATE |
| Nausea | 4346 (3 reviews) |
Serious | Not serious | Serious | Not serious | Strong association | +++◯ MODERATE |
| Pruritus | 2865 (1 review) |
Serious | Not serious | Very serious | Not serious | None | +◯◯◯ VERY LOW |
| Vomiting | 3368 (2 reviews) |
Serious | Not serious | Very serious | Not serious | Strong association | ++◯◯ LOW |