14. GRADE quality judgement: opioids versus active pharmacological comparator.

	Participants (reviews)	Risk of bias	Inconsistency	Indirectness	Imprecision	Other considerations	Overall quality of evidence
Any adverse event	1583 (1 review)	Serious	Not serious	Not serious	Not serious	None	+++◯ MODERATE
Any serious adverse event	108 (1 review)	Serious	Not serious	Not serious	Very serious	None	+◯◯◯ VERY LOW
Withdrawals due to adverse events	2375 (4 reviews)	Serious	Not serious	Not serious	Not serious	None	+++◯ MODERATE