Trial name or title | Progesterone after previous preterm birth for prevention of neonatal respiratory distress syndrome: the PROGRESS trial |
Methods | Randomised, double‐blind, placebo‐controlled trial |
Participants | 787 women recruited Women were eligible if they had a live fetus (singleton or twins), between 18 and 23 + 6 weeks' gestation and a history of prior preterm birth at < 37 weeks' gestation in the immediately preceding pregnancy (where the onset of labour occurred spontaneously, or in association with cervical incompetence, or following preterm prelabour ruptured membranes) |
Interventions |
Intervention: nightly vaginal pessaries of 100 mg progesterone from 20 weeks' gestation until birth or 34 weeks' gestation Control: nightly vaginal pessaries of similar‐appearing placebo, from 20 weeks' gestation until birth or 34 weeks' gestation |
Outcomes | Preterm birth Infant respiratory distress syndrome |
Starting date | Not clear |
Contact information | Caroline Crowther caroline.crowther@adelaide.edu.au |
Notes | Waiting for trial to be published. Will be included when results are available |