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. 2017 Oct 31;2017(10):CD012024. doi: 10.1002/14651858.CD012024.pub2
Trial name or title Progesterone after previous preterm birth for prevention of neonatal respiratory distress syndrome: the PROGRESS trial
Methods Randomised, double‐blind, placebo‐controlled trial
Participants 787 women recruited
Women were eligible if they had a live fetus (singleton or twins), between 18 and 23 + 6 weeks' gestation and a history of prior preterm birth at < 37 weeks' gestation in the immediately preceding pregnancy (where the onset of labour occurred spontaneously, or in association with cervical incompetence, or following preterm prelabour ruptured membranes)
Interventions Intervention: nightly vaginal pessaries of 100 mg progesterone from 20 weeks' gestation until birth or 34 weeks' gestation
Control: nightly vaginal pessaries of similar‐appearing placebo, from 20 weeks' gestation until birth or 34 weeks' gestation
Outcomes Preterm birth
Infant respiratory distress syndrome
Starting date Not clear
Contact information Caroline Crowther
caroline.crowther@adelaide.edu.au
Notes Waiting for trial to be published. Will be included when results are available