Dionne 1998.
Methods | RCT, DB, single oral dose, 4 parallel groups Medication administered when baseline pain was of moderate to severe intensity Pain assessed at 0, 15, 30, 45, 60 minutes, then hourly to 6 hours |
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Participants | Third molar extraction N = 181 (176 analysed for efficacy) M = 50, F = 126 Mean age 22 years |
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Interventions | Dexibuprofen (S(+)‐Ibuprofen) 200 mg, n = 51 Dexibuprofen (S(+)‐Ibuprofen) 400 mg, n = 50 Ibuprofen (racemic) 400 mg, n = 50 Placebo, n = 25 |
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Outcomes | PI: std 4 point scale and 100 mm VAS PR: std 5 point scale and 100 mm VAS Time to use of rescue medication Withdrawals |
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Notes | Oxford Quality Score: R1, DB2, W1 Rescue medication permitted ‐ no further details |
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Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Not specified |
Allocation concealment (selection bias) | Unclear risk | Not specified |
Blinding (performance bias and detection bias) All outcomes | Low risk | "Double‐dummy method" |
Size | High risk | < 50 participants per treatment group |