Dionne 1998.

Methods	RCT, DB, single oral dose, 4 parallel groups Medication administered when baseline pain was of moderate to severe intensity Pain assessed at 0, 15, 30, 45, 60 minutes, then hourly to 6 hours
Participants	Third molar extraction N = 181 (176 analysed for efficacy) M = 50, F = 126 Mean age 22 years
Interventions	Dexibuprofen (S(+)‐Ibuprofen) 200 mg, n = 51 Dexibuprofen (S(+)‐Ibuprofen) 400 mg, n = 50 Ibuprofen (racemic) 400 mg, n = 50 Placebo, n = 25
Outcomes	PI: std 4 point scale and 100 mm VAS PR: std 5 point scale and 100 mm VAS Time to use of rescue medication Withdrawals
Notes	Oxford Quality Score: R1, DB2, W1 Rescue medication permitted ‐ no further details
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Not specified
Allocation concealment (selection bias)	Unclear risk	Not specified
Blinding (performance bias and detection bias) All outcomes	Low risk	"Double‐dummy method"
Size	High risk	< 50 participants per treatment group