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. Author manuscript; available in PMC: 2019 Apr 26.
Published in final edited form as: Arch Toxicol. 2016 Dec 18;91(8):2837–2847. doi: 10.1007/s00204-016-1908-3

Table 1.

IC50 (M) of reversible inhibitors for 0.1 and 1 mM ATCh and BTCh

Substrate
Inhibitor 0.1 mM ATCh 1 mM ATCh 0.1 mM BTCh 1 mM BTCh
Ethopropazine 9.3± 3.1 × 10−5 1.3± 0.5 × 10−4 9.1± 2.1 × 10−5 2.2±0.7 × 10−4
BW284c51 2.0± 0.3 × 10−5 3.2± 0.3 × 10−5 2.3± 0.3 × 10−5 8.9± 0.3 × 10−5
Donepezil 8.9± 0.6 ×10−5 6.9± 0.2 ×10−5 NDa NDa
Edrophonium 3.1± 0.1 × 10−5 1.6±0.2 × 10−4 NDa NDa
Tacrine 6.2± 0.6 × 10−5 1.4±0.1 × 10−4 NDa NDa
Propidium >3.0 × 10−4 >3.0 × 10−4 NDa NDa

IC50 values given as the mean±SE of at least 2 independent experiments (shown in Fig. 2)

a

ND, not determined.