Table 1.
IC50 (M) of reversible inhibitors for 0.1 and 1 mM ATCh and BTCh
Substrate | ||||
---|---|---|---|---|
Inhibitor | 0.1 mM ATCh | 1 mM ATCh | 0.1 mM BTCh | 1 mM BTCh |
Ethopropazine | 9.3± 3.1 × 10−5 | 1.3± 0.5 × 10−4 | 9.1± 2.1 × 10−5 | 2.2±0.7 × 10−4 |
BW284c51 | 2.0± 0.3 × 10−5 | 3.2± 0.3 × 10−5 | 2.3± 0.3 × 10−5 | 8.9± 0.3 × 10−5 |
Donepezil | 8.9± 0.6 ×10−5 | 6.9± 0.2 ×10−5 | NDa | NDa |
Edrophonium | 3.1± 0.1 × 10−5 | 1.6±0.2 × 10−4 | NDa | NDa |
Tacrine | 6.2± 0.6 × 10−5 | 1.4±0.1 × 10−4 | NDa | NDa |
Propidium | >3.0 × 10−4 | >3.0 × 10−4 | NDa | NDa |
IC50 values given as the mean±SE of at least 2 independent experiments (shown in Fig. 2)
ND, not determined.