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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Clin Perinatol. 2019 Mar 30;46(2):327–347. doi: 10.1016/j.clp.2019.02.012

Table 1:

Pharmacodynamic considerations when dosing antimicrobials

Killing pattern Antimicrobial Drug Goal of Dosing PK/PD parameter
Concentration-dependent killing Aminoglycosides Maximize Peak (Cmax) High dose, long dosing interval Cmax/MIC
Time-dependent killing Penicillins
Carbapenams
Cephalosporins		 Maximize duration of exposure above MIC Short dosing interval and long infusion times % time >MIC
AUC-dependent killing Vancomycin
Fluconazole		 Maximize Cmax and duration of exposure above MIC. High dose and short interval AUC24/MIC

Adapted from Table 37-3, Remington and Klein’s Infectious Disease of the Fetus and Newborn. 8th edition. Elsevier: Philadelphia. Saunders; 2016; with permission.