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. Author manuscript; available in PMC: 2019 Apr 26.
Published in final edited form as: Cell Rep. 2019 Apr 16;27(3):955–970.e7. doi: 10.1016/j.celrep.2019.03.071

Figure 3. Examples of TF-TF Co-binding and Indirect Binding in Genomic Regions.

Figure 3.

(A) Schematic representation of Cyc-Foxo co-binding on DNA.

(B) Cyc-Foxo co-binding is observed in the promoter region of vrille. GOMER tracks indicate motif enrichment for each TF.

(C) Schematic representation of Hr78 indirect DNA binding through Hairy.

(D) Hr78 indirect binding through Hairy is observed in the promoter region of kayak. GOMER tracks indicate motif enrichment for each TF. “S14 Regions” track indicates open chromatin regions derived from DNase-seq experiments performed at 10–11 h post-hatch (Li et al., 2011) (retrieved from the University of California, Santa Cruz [UCSC] Genome Browser), corresponding to the co-expressed time points of the 2 TFs.