Table 1.

Experimentally Identified Drosophila TF-TF PPIs

Study	Method	Total no. PPIs Detected	No. of TF-TF Interactionsa
Giot et al., 2003	Y2H	20,405	341
Stanyon et al., 2004	Y2H	1,814	19
Formstecher et al., 2005	Y2H	2,338	53
Guruharsha et al., 2011	AP-MS	209,912	221
Lowe et al., 2014	AP-MS	14,932	21
Rhee et al., 2014	AP-MS	174,561	23
MasterNet (PPIs detected for Drosophila proteins)	compilation	–	1,161
MasterNet (including PPIs inferred from Interologs)	compilation	–	4,606
This study	Y2H	–	1,983

^aNumbers retrieved from MasterNet.