Table 2.
Evidence of Interacting TFs Found in ChIP Data
| Binding Mode | PPI | TF1 (ChIP-Profiled TF) | Adjusted p | TF2 | Adjusted p | Overlapping Expression Patterns | ChIP Data Ref. | Time Point of ChIP Data |
|---|---|---|---|---|---|---|---|---|
| Co-binding | bcd Rel* | bcd | 1.01E-40 | Rel | 9.16E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, adult female | Paris et al., 2013 | E2–4 |
| Co-binding | bcd Rel* | bcd | 2.47E-7 | Rel | 4.72E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, adult female | MacArthur et al., 2009 | E2–3 |
| Co-binding | bcd ttk | bcd | 2.47E-7 | ttk | 4.29E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, adult female | MacArthur et al., 2009 | E2–3 |
| Co-binding | cyc foxo* | cyc | 1.74E-15 | foxo | 1.86E-4 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | Meireles-Filho et al., 2014 | adult female |
| Co-binding | cyc foxo* | cyc | 4.07E-12 | foxo | 3.44E-5 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | Meireles-Filho et al., 2014 | adult female |
| Co-binding | Dttk | D | 4.99E-5 | ttk | 6.78E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | E1–12 |
| Co-binding | da caup* | da | 2.43E-2 | caup | 2.43E-2 | E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | MacArthur et al., 2009 | E2–3 |
| Co-binding | da foxo* | da | 2.43E-2 | foxo | 6.23E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | MacArthur et al., 2009 | E2–3 |
| Co-binding | da twi | da | 2.43E-2 | twi | 9.22E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | MacArthur et al., 2009 | E2–3 |
| Co-binding | hth exd* | hth | 1.81E-3 | exd | 1.86E-4 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | E0–8 |
| Co-binding | hth Ubx | hth | 1.81E-3 | Ubx | 1.47E-4 | E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | E0–8 |
| Co-binding | Kr Hr78* | Kr | 2.96E-45 | Hr78 | 8.30E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae | Paris et al., 2013 | E2–4 |
| Co-binding | Kr Hr78* | Kr | 4.16E-60 | Hr78 | 4.98E-4 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae | Paris et al., 2013 | E2–4 |
| Co-binding | Kr ovo | Kr | 4.16E-60 | ovo | 6.44E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae | Paris et al., 2013 | E2–4 |
| Co-binding | Kr Ptx1* | Kr | 4.16E-60 | Ptx1 | 6.08E-4 | E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae | Paris et al., 2013 | E2–4 |
| Co-binding | Trl foxo* | Trl | 3.93E-24 | foxo | 4.09E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | E8–16 |
| Co-binding | Trl ken | Trl | 3.93E-24 | ken | 6.23E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | E8–16 |
| Co-binding | zld Kah* | zld | 1.88E-118 | Kah | 4.79E-46 | E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | Harrison et al., 2011 | E2–2.5 |
| Co-binding | zld Kah* | zld | 9.75E-123 | Kah | 1.85E-41 | E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | Harrison et al., 2011 | E3–3.5 |
| Co-binding | zld mirr* | zld | 1.88E-118 | mirr | 6.23E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | Harrison et al., 2011 | E2–2.5 |
| Co-binding | zld mirr* | zld | 9.75E-123 | mirr | 4.09E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | Harrison et al., 2011 | E3–3.5 |
| Indirect | br Zif* | br | 1.00E+00 | Zif | 9.81E-2 | E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | WPP |
| Indirect | Dll CG3919* | Dll | 1.00E+00 | CG3919 | 3.63E-2 | E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female |
modENCODE Consortium et al., 2010 | WPP |
| Indirect | Dll mirr* | Dll | 1.00E+00 | mirr | 3.63E-2 | E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | WPP |
| Indirect | Dll rn* | Dll | 1.00E+00 | rn | 2.07E-7 | E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | WPP |
| Indirect | EcR Rel* | EcR | 8.34E-1 | Rel | 6.15E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | Shlyueva et al., 2014 | WPP |
| Indirect | gt lola | gt | 5.07E-1 | lola | 6.23E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | Paris et al., 2013 | E2–4 |
| Indirect | gt lola | gt | 7.22E-1 | lola | 8.89E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | Paris et al., 2013 | E2–4 |
| Indirect | Gtttk | gt | 5.07E-1 | ttk | 5.65E-3 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | Paris et al., 2013 | E2–4 |
| Indirect | Hr78 bowl* | Hr78 | 1.00E+00 | bowl | 6.81E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | E8–16 |
| Indirect | Hr78 disco* | Hr78 | 1.00E+00 | disco | 6.81E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | E8–16 |
| Indirect | Hr78 Doc2* | Hr78 | 1.00E+00 | Doc2 | 1.47E-4 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae | modENCODE Consortium et al., 2010 | E8–16 |
| Indirect | Hr78 E (spl)m3-HLH* | Hr78 | 1.00E+00 | E(spl) m3-HLH | 4.54E-2 | E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female |
modENCODE Consortium et al., 2010 | E8–16 |
| Indirect | Hr78 E (spl)mdelta-HLH* | Hr78 | 1.00E+00 | E(spl) mdelta-HLH | 9.14E-5 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E22–24, L3, WPP, pupae | modENCODE Consortium et al., 2010 | E8–16 |
| Indirect | Hr78 ey* | Hr78 | 1.00E+00 | ey | 6.10E-5 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | E8–16 |
| Indirect | Hr78 Fer3* | Hr78 | 1.00E+00 | Fer3 | 3.25E-2 | E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, pupae, adult male | modENCODE Consortium et al., 2010 | E8–16 |
| Indirect | Hr78 h* | Hr78 | 1.00E+00 | h | 1.31E-3 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | E8–16 |
| Indirect | Hr78 Max* | Hr78 | 1.00E+00 | Max | 4.72E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | E8–16 |
| Indirect | Hr78 Mondo | Hr78 | 1.00E+00 | Mondo | 9.16E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | E8–16 |
| Indirect | Hr78 sna | Hr78 | 1.00E+00 | sna | 1.31E-3 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae | modENCODE Consortium et al., 2010 | E8–16 |
| Indirect | Hr78 sv | Hr78 | 1.00E+00 | sv | 1.31E-3 | E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | E8–16 |
| Indirect | Hr78 Trl | Hr78 | 1.00E+00 | Trl | 7.55E-4 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | E8–16 |
| Indirect | Hr78 zfh1 | Hr78 | 1.00E+00 | zfh1 | 3.25E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | E8–16 |
| Indirect | kn Xbp1 | kn | 1.00E+00 | Xbp1 | 3.43E-2 | E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male | modENCODE Consortium et al., 2010 | E0–12 |
| Indirect | prd Hr78 | prd | 1.00E+00 | Hr78 | 6.23E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E22–24, L3, WPP, pupae, adult male | modENCODE Consortium et al., 2010 | E0–12 |
| Indirect | Su(H) da | Su(H) | 0.999999984 | da | 4.72E-2 | E0–2, E2–4, E4–6, E6–8, E8–10, E10–12, E12–14, E14–16, E16–18, E18–20, E20–22, E22–24, L1, L2, L3, WPP, pupae, adult male, adult female | modENCODE Consortium et al., 2010 | E0–8 |
Some interactions are listed twice because these pairs were found in multiple ChIP samples.
*
Interactions found in Y2H.