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(A) HA phylogenic relationship between the different evaluated subtypes. Mice were immunized with a vaccine containing the HA stalk domain of H1, and cross-reactivity of the elicited Abs was evaluated in pooled sera to full- length H2 (B), H18 (C), H9 (D), and H3 (F) HAs. The reactivity to H9 HA was also measured in individual mouse sera (E). Bars are means. *p , 0.05, ****p , 0.0001. The levels of N1-reactive Abs are shown in (G).
