Neto 1990.

Methods	Quasi‐randomised controlled trial
Participants	80 women with normal labour and episiotomy in 1 public hospital, recruited between October 1988 and September 1989.
Interventions	Intervention arm received oral chloramphenicol 500 mg 4 times daily for 72 hours after episiotomy repair. Control arm received no treatment.
Outcomes	A total of 73 women included in analysis, 34 in intervention arm and 39 in control arm. Outcomes measured included episiotomy dehiscence (wound rupture without signs of infection), episiotomy infection (pain, heat, redness, or purulent discharge and wound rupture), and puerperal endometritis assessed at 10 days postpartum (defined as 2 of the following; fever, hypogastric pain, uterine involution, abnormal lochia).
Notes	Florianopolis, Brazil. Exclusion of 7 women lost to follow‐up at 10 days postpartum. All women were from low socioeconomic class. All women attended by registrars. Funding: not reported. Conflicts of interest: not reported.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	High risk	Randomised according to protocol number (even and odd numbers)
Allocation concealment (selection bias)	High risk	Allocation concealment based on protocol number
Blinding of participants and personnel (performance bias) All outcomes	High risk	Not double‐blinded. Control arm received no treatment
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Unknown. No information on whether physicians who evaluated the women at 10 days postpartum were blinded to the treatment allocation.
Incomplete outcome data (attrition bias) All outcomes	High risk	6 women in intervention group and 1 in control group were missing for follow‐up, but no differences reported in baseline characteristics among those followed‐up.
Selective reporting (reporting bias)	Low risk	All outcomes were reported.
Other bias	Low risk	No other sources of bias noted.