Comparison 2. Oesophageal pH probe study parameters.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Reflux Index (percentage of time pH < 4)	2	116	Mean Difference (IV, Fixed, 95% CI)	‐5.08 [‐8.89, ‐1.28]
1.1 Carob bean gum	1	20	Mean Difference (IV, Fixed, 95% CI)	‐3.90 [‐9.36, 1.56]
1.2 Cornstarch	1	96	Mean Difference (IV, Fixed, 95% CI)	‐6.20 [‐11.50, ‐0.90]
2 Number of reflux episodes lasting > 5 minutes	2	116	Mean Difference (IV, Fixed, 95% CI)	‐3.40 [‐5.44, ‐1.36]
2.1 Carob bean gum	1	20	Mean Difference (IV, Fixed, 95% CI)	‐3.4 [‐7.06, 0.26]
2.2 Cornstarch	1	96	Mean Difference (IV, Fixed, 95% CI)	‐3.40 [‐5.85, ‐0.95]
3 Duration of longest reflux episode (minutes)	2	116	Mean Difference (IV, Fixed, 95% CI)	‐12.41 [‐23.25, ‐1.58]
3.1 Carob bean gum	1	20	Mean Difference (IV, Fixed, 95% CI)	‐1.80 [‐24.63, 21.03]
3.2 Cornstarch	1	96	Mean Difference (IV, Fixed, 95% CI)	‐15.5 [‐27.81, ‐3.19]