Comparison 1. Vitamin D versus placebo or no intervention.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 All‐cause mortality	15	1034	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.70 [0.09, 5.38]
2 All‐cause mortality ('best‐worst' case and 'worst‐best' case scenarios)	15		Peto Odds Ratio (Peto, Fixed, 95% CI)	Subtotals only
2.1 'Best‐worst' case scenario	15	1034	Peto Odds Ratio (Peto, Fixed, 95% CI)	0.11 [0.05, 0.24]
2.2 'Worst‐best' case scenario	15	1034	Peto Odds Ratio (Peto, Fixed, 95% CI)	7.80 [3.67, 16.57]
3 Liver‐related mortality	1	18	Risk Ratio (M‐H, Random, 95% CI)	1.62 [0.08, 34.66]
4 Serious adverse events	3		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
4.1 Hypercalcaemia	1	76	Risk Ratio (M‐H, Random, 95% CI)	5.0 [0.25, 100.80]
4.2 Myocardial infarction	2	86	Risk Ratio (M‐H, Random, 95% CI)	0.75 [0.08, 6.81]
4.3 Thyroiditis	1	68	Risk Ratio (M‐H, Random, 95% CI)	0.33 [0.01, 7.91]
5 Non‐serious adverse events	1		Risk Ratio (M‐H, Random, 95% CI)	Subtotals only
5.1 Glossitis	1	65	Risk Ratio (M‐H, Random, 95% CI)	3.70 [0.16, 87.58]
6 Failure of rapid virological response	2	187	Risk Ratio (M‐H, Random, 95% CI)	0.70 [0.52, 0.94]
7 Failure of early virological response	2	140	Risk Ratio (M‐H, Random, 95% CI)	0.10 [0.03, 0.33]
8 Failure of sustained virological response	5	422	Risk Ratio (M‐H, Random, 95% CI)	0.59 [0.28, 1.21]
9 Acute cellular rejection in liver transplant recipients	1	75	Risk Ratio (M‐H, Random, 95% CI)	0.33 [0.04, 2.62]
10 Vitamin D status (ng/mL)	6	424	Mean Difference (IV, Random, 95% CI)	17.24 [12.46, 22.02]
11 Biochemical indices	6		Mean Difference (IV, Random, 95% CI)	Subtotals only
11.1 Aspartate aminotransferase (IU/L)	6	313	Mean Difference (IV, Random, 95% CI)	‐1.40 [‐2.88, 0.08]
11.2 Alanine aminotransferase (IU/L)	6	313	Mean Difference (IV, Random, 95% CI)	‐0.52 [‐5.10, 4.06]
11.3 Alkaline phosphatases (IU/L)	2	96	Mean Difference (IV, Random, 95% CI)	7.39 [‐39.89, 54.67]
11.4 Gamma‐glutamyl transpeptidase (IU/L)	2	101	Mean Difference (IV, Random, 95% CI)	3.64 [0.33, 6.96]
11.5 Albumin (g/L)	2	48	Mean Difference (IV, Random, 95% CI)	‐0.10 [‐0.40, 0.20]
11.6 Bilirubin (mg/dL)	2	48	Mean Difference (IV, Random, 95% CI)	0.38 [0.21, 0.55]
11.7 Triglyceride (mg/dL)	2	115	Mean Difference (IV, Random, 95% CI)	23.69 [‐13.90, 61.27]
11.8 Cholesterol (mg/dL)	1	55	Mean Difference (IV, Random, 95% CI)	2.75 [‐4.75, 10.25]
11.9 Calcium (mg/dL)	2	72	Mean Difference (IV, Random, 95% CI)	2.01 [‐0.53, 4.56]