| Study ID |
Saline concentration |
Saline volume |
Bronchodilator administered |
Administration interval |
Treatment duration |
| Outpatient trials |
| Li 2014 |
3%, 5% |
3 mL |
None |
Twice daily |
3 days |
| Sarrell 2002 |
3% |
2 mL |
Terbutaline 5 mg |
Every 8 hours |
5 days |
| Emergency department trials |
| Al‐Ansari 2010 |
3%, 5% |
5 mL |
Epinephrine 1.5 mL |
Every 4 hours |
Until discharge |
| Anil 2010 |
3% |
4 mL |
Epinephrine 1.5 mL or salbutamol 2.5 mg |
Every 30 minutes |
Until 2 doses had been administered |
| Florin 2014 |
3% |
4 mL |
None |
Within 90 minutes after albuterol administration |
Single dose |
| Grewal 2009 |
3% |
2.5 mL |
2.25% racemic epinephrine 0.5 mL |
If needed, the second dose was given during the 120‐minute study period. |
Up to 2 doses |
| Ipek 2011 |
3% |
4 mL |
Salbutamol 0.15 mg/kg |
Every 20 minutes |
Until 3 doses had been administered |
| Jacobs 2014 |
7% |
3 mL |
Racemic epinephrine 0.5 mL |
Study solution was given after initial screening and assessment. |
Single dose (if the infant was admitted, the same solution was given every 6 h until discharge or 24 h after the admission). |
| Khanal 2015 |
3% |
4 mL |
Epinephrine 1.5 mg |
Study solution was given at 0 and 30 minutes. |
Until 2 doses had been administered |
| Wu 2014 |
3% |
4 mL |
None |
Emergency department physicians could order 2 additional doses every 20 minutes. |
Up to 3 doses |
| Angoulvant 2017 |
3% |
4 mL |
None |
Study solution was given at 0 and 30 minutes. |
Until 2 doses had been administered |
| Inpatient trials |
| NCT01238848 |
3% |
3 mL |
Albuterol 0.25 mg/kg/day |
4 times a day |
5 days |
| Everard 2014 |
3% |
4 mL |
None |
Every 6 hours |
Until fit for discharge |
| Flores 2016 |
3% |
3 mL |
Salbutamol 0.25 mL (1.25 mg) |
Every 6 hours |
Until discharge |
| Mahesh Kumar 2013 |
3% |
3 mL |
Salbutamol 0.15 mg/kg |
Every 6 hours |
Until ready for discharge |
| Miraglia Del Giudice 2012 |
3% |
? mL |
Epinephrine 1.5 mg |
Every 6 hours |
Until discharge |
| Köse 2016 |
3%, 7% |
2.5 mL |
Salbutamol 0.15 mg/kg |
2 doses were given at 30‐minute interval, followed by every 6 hours. |
Until discharge |
| Kuzik 2007 |
3% |
4 mL |
Albuterol was added in 37% of the treatments, and racemic epinephrine was added in 23% of the treatments by attending physicians. |
Every 2 hours for 3 doses, followed by every 4 hours for 5 doses, and then every 6 hours |
Until discharge |
| Luo 2010 |
3% |
4 mL |
Salbutamol 2.5 mg |
Every 8 hours |
Until discharge |
| Luo 2011 |
3% |
4 mL |
None |
Every 2 hours for 3 doses, followed by every 4 hours for 5 doses, and then every 6 hours |
Until discharge |
| Mandelberg 2003 |
3% |
4 mL |
Epinephrine 1.5 mg |
Every 8 hours |
Until discharge |
| Sharma 2013 |
3% |
4 mL |
Salbutamol 2.5 mg |
Every 4 hours |
Until ready for discharge |
| Pandit 2013 |
3% |
4 mL |
Epinephrine 1.0 mL |
3 doses were given at 1‐hour intervals, followed by every 6 hours. |
Until discharge |
| Ojha 2014 |
3% |
4 mL |
None |
Every 8 hours |
Until discharge |
| Ratajczyk‐Pekrul 2016 |
3% |
3 mL |
Salbutamol 0.15 mg/kg |
Every 4 hours |
Until discharge |
| Tal 2006 |
3% |
4 mL |
Epinephrine 1.5 mg |
Every 8 hours |
Until discharge |
| Teunissen 2014 |
3%, 6% |
4 mL |
Salbutamol 2.5 mg |
Every 8 hours |
Until discharge |
| Tinsa 2014 |
5% |
4 mL |
Epinephrine 2 mL |
Every 4 hours |
Until discharge |
