Ojha 2014.

Methods	Design: randomised, double‐blind, parallel‐group, controlled trial
Participants	Setting: inpatient ward of a teaching hospital in Nepal Assessed for eligibility: 104 Randomised: 36 hypertonic saline group; 36 normal saline group Completed: 28 hypertonic saline group; 31 normal saline group Gender (male): 74% Age (mean ± SD): 8.5 ± 5.0 months Inclusion criteria: children aged over 6 weeks up to 24 months, hospitalised with acute bronchiolitis, defined as the first episode of wheezing associated with tachypnoea, increased respiratory effort, and an upper respiratory tract infection Exclusion criteria: previous episode of wheezing, chronic cardiac and pulmonary disease, immunodeficiency, accompanying respiratory failure, requiring mechanical ventilation, inhaling the nebulised 3% hypertonic saline solution and salbutamol 12 h before treatment, premature infants born at less than 34 weeks gestation, SaO₂ < 85% on room air
Interventions	Intervention group: nebulised 3% hypertonic saline (4 mL) Control group: nebulised 0.9% normal saline (4 mL) The treatment was given every 8 h until discharge.
Outcomes	Length of hospital stay Clinical severity score Duration of oxygen supplementation
Notes	Virological identification not available.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated randomisation
Allocation concealment (selection bias)	Low risk	The random numbers were kept in a sealed envelope. The solutions looked similar in appearance and smell and were kept in 2 identical containers, labelled only by a code number.
Blinding (performance bias and detection bias) All outcomes	Low risk	Double‐blind
Incomplete outcome data (attrition bias) All outcomes	Low risk	13 (18%) withdrawals after randomisation (8 hypertonic saline group; 5 normal saline group); baseline characteristics between treatment groups were balanced.
Selective reporting (reporting bias)	Low risk	All predefined outcomes reported.
Other bias	Low risk	No other bias found.