Sharma 2013.

Methods	Design: randomised, double‐blind, parallel‐group, controlled trial
Participants	Setting: inpatient ward of a tertiary care teaching hospital in India Assessed for eligibility: 277 Randomised: 125 hypertonic saline group; 125 normal saline group Completed: 125 hypertonic saline group; 123 normal saline group Gender (male): 76.2% Age (mean ± SD): 8.5 ± 5.0 months Inclusion criteria: infants aged 1 to 24 months, hospitalised with moderate (clinical severity score 3 to 6) acute bronchiolitis, defined by the first episode of wheezing along with prodrome of upper respiratory tract infection Exclusion criteria: children with obtunded consciousness, cardiac disease, chronic respiratory disease, previous wheezing episode, progressive respiratory distress requiring respiratory support other than supplemental oxygen, use of nebulised hypertonic saline within the previous 12 h
Interventions	Intervention group: nebulised 3% hypertonic saline (4 mL) plus salbutamol (2.5 mg) Control group: nebulised 0.9% normal saline (4 mL) plus salbutamol (2.5 mg) The medication was given via a jet nebuliser with tight‐fitting face mask, driven by oxygen flow at 7 L/min, every 4 h until the infant was ready for discharge.
Outcomes	Length of hospital stay Wang clinical severity score Adverse events
Notes	Virological identification not available.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer‐generated randomisation
Allocation concealment (selection bias)	Low risk	Study solutions were similar in colour, smell, and other physical properties. The code of the therapeutic package (hypertonic saline versus normal saline solution) was deposited with the statistician.
Blinding (performance bias and detection bias) All outcomes	Low risk	Double‐blind
Incomplete outcome data (attrition bias) All outcomes	Low risk	2 (0.8%) withdrawals after randomisation in normal saline group
Selective reporting (reporting bias)	Low risk	All predefined outcomes reported.
Other bias	Low risk	No other bias found.